While the presentation is more often that of a political comedy than horror, the subject matter can easily be stolen for a Delta Green or Modern game. In fact, I'm doing that right now! Think Alien Raiders, but with more comedy.
Documentary filmmaker Laurel Healy agrees to take a job working for her brother, Democratic Senator Luke Healy, in order to secure funding for her next film. However, she comes across a conspiracy in which alien bugs have partially replaced the brains of several people, including members of Congress. Sometimes, the bugs cause their victims' heads to explode. The song "You Might Think" by The Cars is used frequently in the series as a leitmotif for characters who are infected by the aliens.
As bonus nerd cred, each episode features a 'previously on' recap song by Jon Coulton. Here's the one from episode 2, minor spoilers for Episode 1.