The crucial point is whether the book is as backwards compatible as they claim. We have seen in the last couple of years a new Cthulhu Invictus edition, taking it up from a monograph, a new Cthulhu By Gaslight, and I believe there is a new Cthulhu Dark Ages in the works. All of these are or will be keyed to the 6th edition. This does not even begin to think about the campaign books.
My inclination is, because I have an 'infrastructure' of 5/6th edition, including extra rules copies for players, is to stick with that. I heard very little in the podcast that I like in any event. The BRP level of success aspect is good for a combat-detailed game, and I would happily use it for a straight up fantasy game, but CoC is a stripped down version of BRP, and always has been, to drag it back in the degree of success business is going to slow things down.
The resistance table can stay--it is described in the podcast as a means of letting the player roll things rather than the keeper--I solve that by letting the player roll, while I determine the dice % needed.
(And as for no maths, I am quite through dumbing down my environment, both in my gaming and everything else.)